Can information regarding the index stillbirth determine risk of adverse outcome in a subsequent pregnancy? Findings from a single‐center cohort study

Abstract Introduction Women with a history of stillbirth have an almost five‐fold increased risk in subsequent pregnancy, as well other adverse maternal and neonatal outcomes. The reasons for this association are not understood but could relate to recurrent causes. We aimed determine whether information from the time index stillbirth, including cause, is associated outcome pregnancy. Material methods A retrospective cohort study was conducted at UK tertiary maternity center. Cases were included if investigated, pregnancy care provided, birth occurred same unit. Data on characteristics, findings investigations, classification death using ReCoDe system extracted, logistic regression performed these factors Results In (n = 266), there 69 outcomes, three perinatal deaths. Preterm delivery (16.2%) birthweight <10th centile (12.4%) most common Of preterm births, 69.8% iatrogenic 47% due abnormalities fetal growth. On multivariate analysis women preexisting medical condition (adjusted odds ratio [aOR] 2.12, 95% CI 1.10‐4.12) those who smoked their (aOR 6.80, 1.99‐23.30) outcome. Neither ( P .61) nor gestation .36) Placental histopathological vascular malperfusion 11.34, 2.20‐58.62), 9.27, 1.09‐78.82), chorioamnionitis 6.35, 1.16‐34.78) These associations independent characteristics. Conclusions examination important, certain placental disorders inform cohort, regarding characteristics cause do provide significant prognostic about pregnancies. Optimal management access smoking cessation essential.